Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression.

ABSTRACT:

Background and purpose

To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and serum PER concentrations was investigated.

Methods

12 patients with sALS from our hospital who agreed to participate and completed the PER for sALS randomized phase 2 study were included. After completing the study, we retrospectively obtained serum PER concentration data from the patients. Based on their mean PER concentrations, we divided the patients who had been taking PER into two groups: four patients with a mean PER concentration of ≥400 ng/mL were assigned to the H group, and three with a mean PER concentration of <400 n

SUBMITTER: Kato H 

PROVIDER: S-EPMC10169924 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature