Human gene and microbial analyses in rectal cancer complete responses to radiotherapy.

ABSTRACT:

Background

The gold standard treatment for locally advanced rectal cancer is total mesorectal excision after preoperative chemoradiotherapy. Response to chemoradiotherapy varies, with some patients completely responding to the treatment and some failing to respond at all. Identifying biomarkers of response to chemoradiotherapy could allow patients to avoid unnecessary treatment-associated morbidity rate. While previous studies have attempted to identify such biomarkers, none have reached clinical utility, which may be due to heterogeneity of the cancer. In this study, potential human gene and microbial biomarkers were explored in a cohort of rectal cancer patients who underwent chemoradiotherapy.

Methods

RNA sequencing was carried out on matched tumour and adjacent normal re

SUBMITTER: Sulit AK 

PROVIDER: S-EPMC10170257 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature