KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is a rare endocrine neoplasia with poor prognosis. Emerging evidence suggests that kinesin family member 11 (KIF11) protein is overexpressed in several tumors and associated with the onset and progression of certain types of cancer; however, its biological functions and mechanisms in ACC progression have not been studied yet. Therefore, this study evaluated the clinical significance and therapeutic potential of the KIF11 protein in ACC.

Methods

The Cancer Genome Atlas (TCGA) database (n=79) and Genotype Tissue Expression (GTEx) database (n=128) were utilized to explore the expression of KIF11 in ACC and normal adrenal tissues. The TCGA datasets were then data mined and statistically analyzed. R survival analysis and univariate and mu

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10170266 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature