Construction and validation of a prognostic model for predicting clear cell renal cell carcinoma based on complement-related genes.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor and is the most common subtype of renal cell carcinoma (RCC). Surgery is used to cure most early ccRCC, but the 5-year overall survival (OS) of ccRCC patients is far from satisfactory. Thus, new prognostic features and therapeutic targets for ccRCC need to be identified. Since complement factors can influence tumor development, we aimed to develop a model to predict the prognosis of ccRCC through complement-related genes.

Methods

Differentially expressed genes were screened from an International Cancer Genome Consortium (ICGC) data set, and the genes associated with prognosis were screened by univariate regression and least absolute shrinkage and selection operator-Cox regression, and column l

SUBMITTER: Qian C 

PROVIDER: S-EPMC10170275 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature