Clinical relevance and distribution of Helicobacter pylori virulence factors in isolates from Chinese patients.

ABSTRACT:

Background

At present, the relationship between virulence factors of Helicobacter pylori (H. pylori) and gastrointestinal diseases is still under discussion. This study investigated the association between distinct virulence factors in H. pylori and different gastrointestinal diseases.

Methods

Gastric biopsy specimens were obtained from 160 patients with different gastrointestinal diseases in China, including 77 patients with chronic gastritis (CG), 36 with peptic ulcer disease (PUD), and 38 with gastric carcinoma (GC). The presence of certain virulence genes was determined by polymerase chain reaction (PCR), and the results were analyzed using chi-squared tests.

Results

A total of 160 H. pylori strains were successfully isolated from gastr

SUBMITTER: Wang X 

PROVIDER: S-EPMC10170277 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature