Narrative review of roles of astrocytes in subarachnoid hemorrhage.

ABSTRACT:

Background and objective

Astrocytes play an important role in healthy brain function, including the development and maintenance of blood-brain barrier (BBB), structural support, brain homeostasis, neurovascular coupling and secretion of neuroprotective factors. Reactive astrocytes participate in various pathophysiology after subarachnoid hemorrhage (SAH) including neuroinflammation, glutamate toxicity, brain edema, vasospasm, BBB disruption, cortical spreading depolarization (SD).

Methods

We searched PubMed up to 31 May, 2022 and evaluated the articles for screening and inclusion for subsequent systemic review. We found 198 articles with the searched terms. After exclusion based on the selection criteria, we selected 30 articles to start the systemic review.

Key content a

SUBMITTER: Luo Y 

PROVIDER: S-EPMC10170286 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature