Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity.

ABSTRACT:

Importance

Pediatric obesity is a growing health care burden. Understanding how the metabolic phenotype of youth with obesity may modify the effect of intestinal fermentation on human metabolism is key to designing early intervention.

Objective

To assess whether adiposity and insulin resistance in youth may be associated with colonic fermentation of dietary fibers and its production of acetate, gut-derived hormone secretion, and adipose tissue lipolysis.

Design, setting, and participants

Cross-sectional study of youths aged 15 to 22 years with body mass index in the 25th to 75th percentile or higher than the 85th percentile for age and sex throughout the New Haven County community in Connecticut. Recruitment, studies, and data collection occurred from June 2018 to Sep

SUBMITTER: Galuppo B 

PROVIDER: S-EPMC10170343 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature