Adeno-associated virus type 2 in US children with acute severe hepatitis.

ABSTRACT: As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA^1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA^3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P < 0.001) and to 0 of 30 patients with hepatitis of defined aetiology (P < 0.001). In controls, HAdV type 41 was d

SUBMITTER: Servellita V 

PROVIDER: S-EPMC10170441 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature