Isopropenyl phosphate as an atom efficient reagent for phosphorylation of alcohols with catalytic base.

ABSTRACT: The atom efficient transesterification of phosphate esters with catalytic base was investigated using an isopropenyl leaving group, generating acetone as the only by-product. The reaction proceeds in good yields at room temperature, with excellent chemoselectivity towards primary alcohols. Mechanistic insights were obtained by obtaining kinetic data using in operando NMR-spectroscopy.

SUBMITTER: Wery J 

PROVIDER: S-EPMC10170494 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature