Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity.

ABSTRACT: Synapse diversity has been described from different perspectives, ranging from the specific neurotransmitters released, to their diverse biophysical properties and proteome profiles. However, synapse diversity at the transcriptional level has not been systematically identified across all synapse populations in the brain. To quantify and identify specific synaptic features of neuronal cell types we combined the SynGO (Synaptic Gene Ontology) database with single-cell RNA sequencing data of the mouse neocortex. We show that cell types can be discriminated by synaptic genes alone with the same power as all genes. The cell type discriminatory power is not equally distributed across synaptic genes as we could identify functional categories and synaptic compartments with greater cell type specif

SUBMITTER: Roig Adam A 

PROVIDER: S-EPMC10170694 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature