Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles.

ABSTRACT:

Background

Most of the resources that support the early development of the embryo are stored in the oocyte. Clearing of maternal resources and activation of the embryonic genome to produce its own mRNA transcripts marks the maternal-to-embryo transition. Dependence on stored mRNA can last from a few hours to several days, depending on animal species. The mechanisms regulating stabilization and recruitment of stored maternal transcripts have not yet been described in full detail but are known to involve reversible polyadenylation and modulation of 3'UTR-mediated elements. RNA epigenetic modifications, new players in this field, have an important role in RNA regulation and stabilization.

Results

The objectives of this study were first to determine if some of post-transcription

SUBMITTER: Dubuc K 

PROVIDER: S-EPMC10170753 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature