Effect of adipokine and ghrelin levels on BMD and fracture risk: an updated systematic review and meta-analysis.

ABSTRACT:

Context

Circulating adipokines and ghrelin affect bone remodeling by regulating the activation and differentiation of osteoblasts and osteoclasts. Although the correlation between adipokines, ghrelin, and bone mineral density (BMD) has been studied over the decades, its correlations are still controversial. Accordingly, an updated meta-analysis with new findings is needed.

Objective

This study aimed to explore the impact of serum adipokine and ghrelin levels on BMD and osteoporotic fractures through a meta-analysis.

Data sources

Studies published till October 2020 in Medline, Embase, and the Cochrane Library were reviewed.

Study selection

We included studies that measured at least one serum adipokine level and BMD or fracture risk in healthy individuals. We exc

SUBMITTER: Lee S 

PROVIDER: S-EPMC10171108 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature