Metabolic biomarkers of risperidone-induced weight gain in drug-naive patients with schizophrenia.

ABSTRACT:

Background

Risperidone is a commonly prescribed antipsychotic drug with a potential side effect of weight gain. However, the pathophysiological mechanism is still poorly understood. Here, we sought to identify potential biomarkers of risperidone-induced weight gain by using a targeted metabolomics approach.

Methods

We enrolled 30 subjects who received risperidone monotherapy for 8  weeks from a prospective longitudinal cohort study for drug-naïve schizophrenia patients. Plasma metabolites were measured by targeted metabolomics Biocrates MxP® Quant 500 Kit at baseline and 8-week follow-up.

Results

After 8  weeks of risperidone treatment, the levels of 48 differential metabolites were upregulated, including lysophosphatidylcholines (2), phosphatidylcholines (PC) (8), ch

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10171109 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature