Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas.

ABSTRACT: Gynecologic carcinosarcomas (CS) are biphasic neoplasms composed of carcinomatous (C) and sarcomatous (S) malignant components. Because of their rarity and histologic complexity, genetic and functional studies on CS are scarce and the mechanisms of initiation and development remain largely unknown. Whole-genome analysis of the C and S components reveals shared genomic alterations, thus emphasizing the clonal evolution of CS. Reconstructions of the evolutionary history of each tumor further reveal that C and S samples are composed of both ancestral cell populations and component-specific subclones, supporting a common origin followed by distinct evolutionary trajectories. However, while we do not find any recurrent genomic features associated with phenotypic divergence, transcriptomic and m

SUBMITTER: Sertier AS 

PROVIDER: S-EPMC10171113 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature