Biologically active sulfur-containing polyamides as promising anticancer materials.

ABSTRACT: Thiazol-based molecules have practically infinite biological implementation. Today, there are many medical applications for compounds containing the thiazole moiety owing to their presence in most clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A and epothilone. In this study, the polycondensation, of a new group of thiazole-containing polyamides with the formulas PA_1-4 was carried out by the interaction of 2-aminothiazole diphenyl sulfide and variable diacid chlorides in dimethyl formamide in the presence of potassium carbonate anhydrous as a catalyst. Fourier transform-infrared spectroscopy (FTIR) was initially used to figure out the PA_1-4 structures, which were further characterized using solubility, gel permeation chrom

SUBMITTER: Ashour GR 

PROVIDER: S-EPMC10171123 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature