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Antimalarial ceramicines Q-T from Chisocheton ceramicus.

ABSTRACT: Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated ¹³C chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanone[α]phenanthren ring system with a β-furyl ring at C-17, and without a tetrahydrofuran ring like ceramicine B, which is characteristic of known ceramicines. Ceramicine R (2) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 2.8 µM.

SUBMITTER: Nugroho AE

PROVIDER: S-EPMC10171166 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Antimalarial ceramicines Q-T from Chisocheton ceramicus.

Nugroho Alfarius Eko AE Wong Chin Piow CP Hirasawa Yusuke Y Kaneda Toshio T Tougan Takahiro T Horii Toshihiro T Hadi A Hamid A AHA Morita Hiroshi H

Journal of natural medicines 20230510 3

Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated <sup>13</sup>C chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanone[α]phenanthren ...[more]

PMID: 37162697

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