Gilteritinib (XOSPATA®) in Turkey: Early Access Program Results.

ABSTRACT:

Background and objectives

Gilteritinib (XOSPATA®, Astellas) is a type I oral FLT3 inhibitor, a tyrosine kinase AXL inhibitor, involved in both c-Kit and FMS-like tyrosine kinase 3 (FLT3) resistance. In the phase 3 ADMIRAL trial, gilteritinib was compared with the standard of care in (R/R) acute myeloid leukemia (AML) patients who harbored any FLT3 mutation and showed superior efficacy with regard to response and survival.

Objectives

This research aimed to investigate the real-life efficacy and safety of gilteritinib in FLT3-positive R/R AML patients who were treated as a part of an early access program held in Turkey in April 2020 (NCT03409081).

Results

The research included 17 R/R AML patients who had received gilteritinib from seven centers. The overall response rat

SUBMITTER: Dogu MH 

PROVIDER: S-EPMC10171205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature