Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.

ABSTRACT: Brain metastases are the most common brain malignancy. This review discusses the studies presented at the third annual meeting of the Melanoma Research Foundation in the context of other recent reports on the biology and treatment of melanoma brain metastases (MBM). Although symptomatic MBM patients were historically excluded from immunotherapy trials, efforts from clinicians and patient advocates have resulted in more inclusive and even dedicated clinical trials for MBM patients. The results of checkpoint inhibitor trials were discussed in conversation with current standards of care for MBM patients, including steroids, radiotherapy, and targeted therapy. Advances in the basic scientific understanding of MBM, including the role of astrocytes and metabolic adaptations to the brain microenv

SUBMITTER: Karz A 

PROVIDER: S-EPMC10171356 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature