Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes.

ABSTRACT: Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited success due to immune evasion mechanisms, coupled with an incomplete understanding of predictors of response. Here, from bulk and single-cell transcriptomic analyses, we identify a subset of neuroblastomas enriched for transcripts associated with immune activation and inhibition and show that these are predominantly characterized by gene expression signatures of the mesenchymal lineage state. By contrast, tumors expressing adrenergic lineage signatures are less immunogenic. The inherent presence or induction of the mesenchymal state through transcriptional reprogramming or therapy resistance is accompanied by innate and adaptive immune gene activation through epigenetic remodeling. Mesenchymal lineage cells p

SUBMITTER: Sengupta S 

PROVIDER: S-EPMC10171398 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature