Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families.

ABSTRACT: The two complete genomic sequences of Helicobacter pylori J99 and 26695 were used to compare the paralogous families (related genes within one genome, likely to have related function) of genes predicted to encode outer membrane proteins which were present in each strain. We identified five paralogous gene families ranging in size from 3 to 33 members; two of these families contained members specific for either H. pylori J99 or H. pylori 26695. Most orthologous protein pairs (equivalent genes between two genomes, same function) shared considerable identity between the two strains. The unusual set of outer membrane proteins and the specialized outer membrane may be a reflection of the adaptation of H. pylori to the unique gastric environment where it is found. One subfamily of proteins, whic

SUBMITTER: Alm RA 

PROVIDER: S-EPMC101716 | biostudies-literature | 2000 Jul

REPOSITORIES: biostudies-literature