Ontology highlight
ABSTRACT:
SUBMITTER: Winkelman MA
PROVIDER: S-EPMC10171804 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Winkelman Max A MA Dai Guohao G
Science advances 20230510 19
Neural progenitor cells (NPCs) have the capability to self-renew and differentiate into neurons and glial cells. In the adult brain, NPCs are found near brain microvascular networks (BMVNs) in specialized microenvironments called the neurovascular niche (NVN). Although several in vitro NVN models have been previously reported, most do not properly recapitulate the intimate cellular interactions between NPCs and perfused brain microvessels. Here, we developed perfused BMVNs composed of primary hu ...[more]