Ontology highlight
ABSTRACT:
SUBMITTER: Restaino AC
PROVIDER: S-EPMC10171812 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Restaino Anthony C AC Walz Austin A Vermeer Samuel J SJ Barr Jeffrey J Kovács Attila A Fettig Robin R RR Vermeer Daniel W DW Reavis Hunter H Williamson Caitlin S CS Lucido Christopher T CT Eichwald Tuany T Omran Dalia K DK Jung Euihye E Schwartz Lauren E LE Bell Maria M Muirhead DesiRae M DM Hooper Jody E JE Spanos William C WC Drapkin Ronny R Talbot Sebastien S Vermeer Paola D PD
Science advances 20230510 19
The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these nerves form functional connections. Consistent with this, electrophysiological analysis shows that malignancies harbor significantly higher electrical activity than benign disease or normal tissues. We also demonstrate pharmacologic silencing of tumoral electrical activity. Tumors implanted in transgenic animals lacking nociceptor ...[more]