Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology.

ABSTRACT: Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable. Detection of both of these aggregates early in the disease process may allow for prophylactic therapies before functional impairments have manifested, highlighting the importance of developing specific imaging probes for these lesions. In contrast to the β sheet dyes, single-domain antibodies, found in camelids and a few other species, are highly specific, and their small size allows better brain entry and distribution than whole antibodies. Here, we have developed such imaging ligands via phage display

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10171817 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature