Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology.
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ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC10171817 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Publications
Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology.
Jiang Yixiang Y Lin Yan Y Krishnaswamy Senthilkumar S Pan Ruimin R Wu Qian Q Sandusky-Beltran Leslie A LA Liu Mengyu M Kuo Min-Hao MH Kong Xiang-Peng XP Congdon Erin E EE Sigurdsson Einar M EM
Science advances 20230510 19
Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable. Detection of both of these aggregates early in the disease process may allow for prophylactic therapies before functional impairments have manifested, highlighting the importance of developing specific imaging ...[more]
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