Dispersion of repolarization increases with cardiac resynchronization therapy and is associated with left ventricular reverse remodeling.

ABSTRACT:

Purpose

Cardiac resynchronization therapy (CRT) reduces ventricular activation times and electrical dyssynchrony, however the effect on repolarization is unclear. In this study, we sought to investigate the effect of CRT and left ventricular (LV) remodeling on dispersion of repolarization using electrocardiographic imaging (ECGi).

Methods

11 patients with heart failure and electrical dyssynchrony underwent ECGi 1-day and 6-months post CRT. Reconstructed epicardial electrograms were used to create maps of activation time, repolarization time (RT) and activation recovery intervals (ARI) and calculate measures of RT, ARI and their dispersion. ARI was corrected for heart rate (cARI).

Results

Compared to baseline rhythm, LV cARI dispersion was significantly higher at 6 mon

SUBMITTER: Elliott MK 

PROVIDER: S-EPMC10171825 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature