PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.

ABSTRACT: Conditional deletion of the PTH1R in mesenchymal progenitors reduces osteoblast differentiation, enhances marrow adipogenesis, and increases zinc finger protein 467 (Zfp467) expression. In contrast, genetic loss of Zfp467 increased Pth1r expression and shifts mesenchymal progenitor cell fate toward osteogenesis and higher bone mass. PTH1R and ZFP467 could constitute a feedback loop that facilitates PTH-induced osteogenesis and that conditional deletion of Zfp467 in osteogenic precursors would lead to high bone mass in mice. Prrx1Cre; Zfp467^fl/fl but not AdipoqCre; Zfp467^fl/fl mice exhibit high bone mass and greater osteogenic differentiation similar to the Zfp467^-/- mice. qPCR results revealed that PTH suppre

SUBMITTER: Liu H 

PROVIDER: S-EPMC10171860 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature