Metabolomic and exposomic biomarkers of risk of future neurodevelopmental delay in human milk.

ABSTRACT:

Background

The chemical composition of human milk has long-lasting effects on brain development. We examined the prognostic value of the human milk metabolome and exposome in children with the risk of neurodevelopmental delay (NDD).

Methods

This retrospective cohort study included 82 mother-infant pairs (40 male and 42 female infants). A total of 59 milk samples were from mothers with typically developing children and 23 samples were from mothers of children at risk. Milk samples were collected before 9 months of age (4.6 ± 2.5 months, mean ± SD). Neurocognitive development was assessed by maternal report at 14.2 ± 3.1 months using the Ages and Stages Questionnaires-2.

Results

Metabolome and exposome profiling identified 453 metabolites and 61 environmental chemicals

SUBMITTER: Li K 

PROVIDER: S-EPMC10172108 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature