Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70^-/- mice with human-like bile acids.

ABSTRACT:

Background

Cyp2c70^-/- mice with a human-like bile acid (BA) composition display features of neonatal cholestasis. We assessed whether perinatal ursodeoxycholic acid (UDCA) exposure prevents neonatal cholestasis in Cyp2c70^-/- mice and reduces cholangiopathy development later in life.

Methods

Cyp2c70^+/- males were crossed with Cyp2c70^+/- females fed either a regular chow diet or a 0.1% UDCA-containing diet during breeding, gestation, and suckling. Cholestasis and liver function parameters were assessed in their Cyp2c70^-/- and wild-type offspring at 3 and 8 weeks of age.

Results

Three-week-old Cyp2c70^-/- pups showed features of neonatal cholestasis, including elevated plasma BAs and transaminases, which we

SUBMITTER: de Vries HD 

PROVIDER: S-EPMC10172110 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature