Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome.

ABSTRACT:

Background

Altered neurometabolite ratios in neonates undergoing cardiac surgery for congenital heart defects (CHD) may serve as a biomarker for altered brain development and neurodevelopment (ND).

Methods

We analyzed single voxel 3T PRESS H¹-MRS data, acquired unilaterally in the left basal ganglia and white matter of 88 CHD neonates before and/or after neonatal cardiac surgery and 30 healthy controls. Metabolite ratios to Creatine (Cr) included glutamate (Glu/Cr), myo-Inositol (mI/Cr), glutamate and glutamine (Glx/Cr), and lactate (Lac/Cr). In addition, the developmental marker N-acetylaspartate to choline (NAA/Cho) was evaluated. All children underwent ND outcome testing using the Bayley Scales of Infant and Toddler Development Third Edition (BSID-III) at 1 yea

SUBMITTER: Steger C 

PROVIDER: S-EPMC10172141 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature