Loss of anti-spike antibodies following mRNA vaccination for COVID-19 among patients with multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) patients have variable responses to mRNA vaccination to COVID-19. Little is known regarding their vaccine-induced antibody levels over time.

Methods

We monitored spike IgG antibody levels over 24 weeks among a subset of 18 MM patients who showed a full response after two mRNA vaccinations.

Results

MM patients had a more rapid decline in antibody levels as compared to eight healthy controls, with power law half-lives of 72 days (vs. 107 days) and exponential half-lives of 37 days (vs. 51 days). The patients with longer SARS-CoV-2 antibody half-lives were more likely to have undetectable monoclonal protein than those with shorter half-lives, suggesting better disease control may correlate with longer duration of vaccine-induced antibodie

SUBMITTER: Stampfer SD 

PROVIDER: S-EPMC10172160 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature