[¹⁸F]FDG Uptake and Expression of Immunohistochemical Markers Related to Glycolysis, Hypoxia, and Proliferation in Indeterminate Thyroid Nodules.

ABSTRACT:

Purpose

The current study explored the association between 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) uptake and the quantitative expression of immunohistochemical markers related to glucose metabolism, hypoxia, and cell proliferation in benign and malignant thyroid nodules of indeterminate cytology.

Procedures

Using a case-control design, 24 patients were selected from participants of a randomized controlled multicenter trial (NCT02208544) in which [¹⁸F]FDG-PET/CT and thyroid surgery were performed for Bethesda III and IV nodules. Three equally sized groups of [¹⁸F]FDG-positive malignant, [¹⁸F]FDG-positive benign, and [¹⁸F]FDG-negative benign nodules were included. Immunohistochemical staining was performed f

SUBMITTER: de Koster EJ 

PROVIDER: S-EPMC10172288 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature