Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy.

ABSTRACT: Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs (miRs) are lipid-rich coronary plaques in 47 statin-treated patients (44 males) with stable coronary artery disease undergoing percutaneous coronary intervention. We assessed lipid content in non-culprit coronary artery lesions with near-infrared spectroscopy and selected the 4 mm segment with the highest measured lipid core burden index (maxLCBI_4mm). Lipid-rich plaques were predefined as a lesion with maxLCBI_4mm ≥ 324.7. We analyzed 177 circulating miRs with quantitative polymerase chain reaction in plasma samples. The associations between miRs an

SUBMITTER: Sæther JC 

PROVIDER: S-EPMC10172303 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature