Glucosylglycerol Extends Chronological Lifespan of the Budding Yeast via an Increased Osmolarity Response.

ABSTRACT: Glucosylglycerol (GG) is an osmolyte that protects cells from extreme conditions. It is produced by sucrose phosphorylase, an enzyme that uses sucrose and glycerol as substrate. GG protects tissue integrity in desert plants during harsh conditions and guards cyanobacteria against high salinity (halotolerant). However, no extensive research has been conducted on the lifespan application of this compound on the yeast Saccharomyces cerevisiae. We designed this study to (1) characterize GG's effect on yeast chronological lifespan (CLS) and (2) to determine the mechanisms underlying its lifespan promotion on strain DBY746. The results obtained in our study confirm that GG causes increased longevity when administered at moderate doses (48 mM and 120 mM). In addition, we discovered that GG

SUBMITTER: Odoh CK 

PROVIDER: S-EPMC10172420 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature