Copper-related genes predict prognosis and characteristics of breast cancer.

ABSTRACT:

Background

The role of copper in cancer treatment is multifaceted, with copper homeostasis-related genes associated with both breast cancer prognosis and chemotherapy resistance. Interestingly, both elimination and overload of copper have been reported to have therapeutic potential in cancer treatment. Despite these findings, the exact relationship between copper homeostasis and cancer development remains unclear, and further investigation is needed to clarify this complexity.

Methods

The pan-cancer gene expression and immune infiltration analysis were performed using the Cancer Genome Atlas Program (TCGA) dataset. The R software packages were employed to analyze the expression and mutation status of breast cancer samples. After constructing a prognosis model to separate bre

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10172490 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature