CD146⁺ mural cells from infantile hemangioma display proangiogenic ability and adipogenesis potential in vitro and in xenograft models.

ABSTRACT:

Objective

Infantile hemangioma (IH), the most common infantile vascular neoplasm, is uniquely characterized by rapid proliferation followed by slow spontaneous involution lasting for years. In IH lesions, perivascular cells are the most dynamic cell subset during the transition from the proliferation phase to the involution phase, and we aimed to systematically study this kind of cell.

Methods and results

CD146-selective microbeads were used to isolate IH-derived mural-like cells (HemMCs). Mesenchymal markers of HemMCs were detected by flow cytometry, and the multilineage differentiation potential of HemMCs was detected by specific staining after conditioned culture. CD146-selected nonendothelial cells from IH samples showed characteristics of mesenchymal stem cells with dis

SUBMITTER: Chen J 

PROVIDER: S-EPMC10172585 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature