Patient-important outcomes in clinical trials of atopic diseases and asthma in the last decade: A systematic review.

ABSTRACT:

Background

Randomized Clinical Trials (RCTs) are important tools to establish the effects of a given intervention. Investigators should focus on outcomes that patients perceive: patient-important outcomes (PIOs), clinical endpoints that patients value directly and reflect how they feel, function, or survive. However, it is easier to consider surrogated outcomes to reduce costs and achieve better-looking results. The problem with these outcomes is that they indirectly measure PIOs, which might not correlate linearly or translate reliably into a positive PIO.

Methods

We systematically searched MEDLINE for atopic disease RCTs rated among the top 10 allergic diseases and general internal medicine journals from the last 10 years. Two independent reviewers worked in duplicate and

SUBMITTER: Gonzalez-Diaz SN 

PROVIDER: S-EPMC10172603 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature