Mycobacterium bovis naturally infected calves present a higher bacterial load and proinflammatory response than adult cattle.

ABSTRACT: Granulomas are characteristic bovine tuberculosis lesions; studying this structure has improved our understanding of tuberculosis pathogenesis. However, the immune response that develops in granulomas of young cattle naturally infected with Mycobacterium bovis (M. bovis) has not been fully studied. Our previous work described an atypical pattern in granulomatous lesions of cattle younger than 4 months (calves) naturally infected previously M. bovis that did not correspond to the histological classification previously proposed. Histologically, granulomas from calves lack a connective tissue capsule and have fewer multinucleated giant cells (MGCs) and more acid-fast bacilli (AFB) than the classic tuberculosis lesions found in cattle older than 1 year (adults); this sugge

SUBMITTER: Carrisoza-Urbina J 

PROVIDER: S-EPMC10172680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature