Hypofractionation: The standard for external beam breast irradiation.

ABSTRACT: This overview provides the historical perspective of external beam breast hypofractionation over the last 50 years. It highlights the serious harm suffered by patients with breast cancer in the 1970's and 1980's because of new hypofractionation regimens based on a theoretical radiobiology model being adopted into clinical practice to solve a resource issue without testing within clinical trials and without the essential radiotherapy quality assurance. It then describes the high-quality clinical trials comparing 3-week with 5-week standard of care regimens that were initiated based on a strong scientific rationale for hypofractionation in breast cancer. Today, there are still challenges with universal implementation of the results of these moderate hypofractionation studies, but there is no

SUBMITTER: Brunt AM 

PROVIDER: S-EPMC10172745 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature