Metastatic breast tumors downregulate miR-145 regulating the hypoxia-induced vasculogenic mimicry.

ABSTRACT: Tumor cells grow in three-dimensional (3D) channels-like structures denoted as vasculogenic mimicry (VM), which provides a route for nutrients and oxygen acquisition. VM is activated by hypoxia and associated with metastasis and poor prognosis. MetastamiRs are microRNAs regulating metastasis, however, if they control VM in breast cancer remains poorly understood. The aim of this study was to evaluate the expression of VM-associated microRNAs in tumors of metastatic breast cancer patients. Firstly, we constructed microRNAs/mRNAs coregulation networks using expression data from TCGA databases. Dozens of microRNAs regulating genes involved in VM and metastasis were found. Of these, we selected 10 microRNAs for further characterization. The presence of VM in histological samples from patients

SUBMITTER: Contreras-Sanzon E 

PROVIDER: S-EPMC10172997 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature