Osteocytes contribute <i>via</i> nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism.

ABSTRACT:

Introduction

The view that bone and energy metabolism are integrated by common regulatory mechanisms is broadly accepted and supported by multiple strands of evidence. This includes the well-characterized role of the PPARγ nuclear receptor, which is a common denominator in energy metabolism and bone metabolism. Little is known, however, about the role of PPARα nuclear receptor, a major regulator of lipid metabolism in other organs, in bone.

Methods

A side-by-side comparative study of 5-15 mo old mice with global PPARα deficiency (α^KO) and mice with osteocyte-specific PPARα deficiency (αOT^KO) in order to parse out the various activities of PPARα in the skeleton that are of local and systemic significance. This study included transcriptome analysis of PPA

SUBMITTER: Chougule A 

PROVIDER: S-EPMC10173151 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature