A chiral metal-organic framework {(HQA)(ZnCl₂)(2.5H₂O)}_n for the enantioseparation of chiral amino acids and drugs.

ABSTRACT: Chiral metal-organic frameworks (CMOFs) with enantiomeric subunits have been employed in chiral chemistry. In this study, a CMOF formed from 6-methoxyl-(8S,9R)-cinchonan-9-ol-3-carboxylic acid (HQA) and ZnCl₂, {(HQA)(ZnCl₂)(2.5H₂O)}_n, was constructed as a chiral stationary phase (CSP) via an in situ fabrication approach and used for chiral amino acid and drug analyses for the first time. The {(HQA)(ZnCl₂)(2.5H₂O)}_n nanocrystal and the corresponding chiral stationary phase were systematically characterised using a series of analytical techniques including scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, circular dichroism, X-ray photoelectron spectroscopy, thermogravi

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10173174 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature