Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort study.

ABSTRACT:

Background

We describe the epidemiology, clinical features and outcome of adult meningococcal meningitis in the Netherlands over a 15-year period.

Methods

We studied adults (age ≥ 16 years) who were listed by the Netherlands Reference Laboratory for Bacterial Meningitis and/or included in the prospective nationwide cohort study (MeninGene) between January 2006 and July 2021. Incidences were calculated per epidemiological year (July-June).

Findings

We identified 442 episodes of adult meningococcal meningitis. The median patient age was 32 years (IQR 18-55) and 226 episodes (51%) occurred in female patients. The annual incidence per 100,000 adults fluctuated, from 0.33 in 2006-2007 to 0.05 in 2020-2021, with a temporal increase up to 0.30 from 2016 to 2018, driven by an

SUBMITTER: van Soest TM 

PROVIDER: S-EPMC10173179 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature