Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication.

ABSTRACT: Cell mechanics is essential to cell development and function, and its dynamics evolution reflects the physiological state of cells. Here, we investigate the dynamical mechanical properties of single cells under various drug conditions, and present two mathematical approaches to quantitatively characterizing the cell physiological state. It is demonstrated that the cellular mechanical properties upon the drug action increase over time and tend to saturate, and can be mathematically characterized by a linear time-invariant dynamical model. It is shown that the transition matrices of dynamical cell systems significantly improve the classification accuracies of the cells under different drug actions. Furthermore, it is revealed that there exists a positive linear correlation between the cytosk

SUBMITTER: Ma S 

PROVIDER: S-EPMC10173291 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature