Changes in the gut microbiota structure and function in rats with doxorubicin-induced heart failure.

ABSTRACT:

Objectives

The rat model of heart failure (HF) induced by doxorubicin (DOX), a broad spectrum and highly effective chemotherapeutic anthracycline with high-affinity to myocardial tissue that causes severe dose-dependent irreversible cardiotoxicity has been widely recognized and applied in HF pathogenesis and drug therapy studies. The gut microbiota (GM) has attracted significant attention due to its potential role in HF, and research in this area may provide beneficial therapeutic strategies for HF. Considering the differences in the route, mode, and total cumulative dose of DOX administration used to establish HF models, the optimal scheme for studying the correlation between GM and HF pathogenesis remains to be determined. Therefore, focusing on establishing the optimal scheme, w

SUBMITTER: Fan Y 

PROVIDER: S-EPMC10173310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature