Viewing Ca²⁺-binding sites in the inositol trisphosphate receptor.

ABSTRACT: Ca²⁺ is a major ligand of the inositol 1,4,5-trisphosphate receptor (IP₃R) Ca²⁺-release channel. Fan et al. [1] recently solved additional cryo-electron microscopy (cryo-EM) structures of the IP₃R in different ligand-binding states, revealing new Ca²⁺ binding sites.

SUBMITTER: Lunko O 

PROVIDER: S-EPMC10173365 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature