Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors.

ABSTRACT: Controlling infection-driven inflammation is a major clinical dilemma because of limited therapeutic options and possible adverse effects on microbial clearance. Compounding this difficulty is the continued emergence of drug-resistant bacteria, where experimental strategies aiming to augment inflammatory responses for enhanced microbial killing are not applicable treatment options for infections of vulnerable organs. As with corneal infections, severe or prolonged inflammation jeopardizes corneal transparency, leading to devastating vision loss. We hypothesized that keratin 6a-derived antimicrobial peptides (KAMPs) may be a two-pronged remedy capable of tackling bacterial infection and inflammation at once. We used murine peritoneal neutrophils and macrophages, together with an in vivo mod

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10173409 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature