Protein Crowding and Cholesterol Increase Cell Membrane Viscosity in a Temperature Dependent Manner.

ABSTRACT: Shear viscosity of lipid membranes dictates how fast lipids, proteins, and other membrane constituents travel along the membrane and rotate around their principal axis, thus governing the rates of diffusion-limited reactions taking place at membranes. In this framework, the heterogeneity of biomembranes indicates that cells could regulate these rates via varying local viscosities. Unfortunately, experiments to probe membrane viscosity under various conditions are tedious and error prone. Molecular dynamics simulations provide an attractive alternative, especially given that recent theoretical developments enable the elimination of finite-size effects in simulations. Here, we use a variety of different equilibrium methods to extract the shear viscosities of lipid membranes from both coarse-

SUBMITTER: Fabian B 

PROVIDER: S-EPMC10173458 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature