Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen.

ABSTRACT:

Background

Caffeine enhances the efficacy of non-opioid analgesics. Data on the cardiovascular health effects of caffeine intake are controversial, and studies on the cardiovascular effects of medical caffeine use are lacking.

Objective

The study aims to explore the cardiovascular effects of an ibuprofen/caffeine combination in comparison to ibuprofen alone.

Methods

Secondary analysis of a previously reported bioequivalence study of a single dose of a fixed dose ibuprofen/caffeine combination (400/100 mg) vs. ibuprofen alone in a randomized, cross-over design in 36 healthy volunteers. Plasma catecholamines were analyzed to enhance mechanistic interpretation of the data.

Results

After exclusion of 10 protocol violators (pre-dosing intake of caffeine), vital sign

SUBMITTER: Lampert A 

PROVIDER: S-EPMC10173466 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature