Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriers.

ABSTRACT:

Background

Sickle cell trait (SCT) refers to the carriage of one abnormal copy of the β-globin gene, the HbS allele. SCT offers protection against malaria, controlling parasite density and preventing progression to symptomatic malaria. However, it remains unclear whether SCT also affects transmission stages and mosquito infection parameters. Deciphering the impact of the SCT on human to mosquito malaria transmission is key to understanding mechanisms that maintain the trait in malaria endemic areas.

Methods

The study was conducted from June to July 2017 among asymptomatic children living in the locality of Mfou, Cameroon. Blood samples were collected from asymptomatic children to perform malaria diagnosis by microscopy, Plasmodium species by PCR and hemoglobin typing by RFLP

SUBMITTER: Ngou CM 

PROVIDER: S-EPMC10173526 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature