Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.

ABSTRACT:

Background

Hybrids are chimeric organisms with highly plastic heterozygous genomes that may confer unique traits enabling the adaptation to new environments. However, most evolutionary theory frameworks predict that the high levels of genetic heterozygosity present in hybrids from divergent parents are likely to result in numerous deleterious epistatic interactions. Under this scenario, selection is expected to favor recombination events resulting in loss of heterozygosity (LOH) affecting genes involved in such negative interactions. Nevertheless, it is so far unknown whether this phenomenon actually drives genomic evolution in natural populations of hybrids. To determine the balance between selection and drift in the evolution of LOH patterns in natural yeast hybrids, we analyzed

SUBMITTER: Mixao V 

PROVIDER: S-EPMC10173528 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature