Hybrid Plasmonic Nanostructures for Enhanced Single-Molecule Detection Sensitivity.

ABSTRACT: Biosensing applications based on fluorescence detection often require single-molecule sensitivity in the presence of strong background signals. Plasmonic nanoantennas are particularly suitable for these tasks, as they can confine and enhance light in volumes far below the diffraction limit. The recently introduced antenna-in-box (AiB) platforms achieved high single-molecule detection sensitivity at high fluorophore concentrations by placing gold nanoantennas in a gold aperture. However, hybrid AiB platforms with alternative aperture materials such as aluminum promise superior performance by providing better background screening. Here, we report on the fabrication and optical characterization of hybrid AiBs made of gold and aluminum for enhanced single-molecule detection sensitivity. We com

SUBMITTER: Herkert EK 

PROVIDER: S-EPMC10173688 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature